Curcumin Suppositories
$89.00
Curcumin vaginal suppositories for cervico-vaginal HPV infection.
24 Ovules • 3 Month Supply
85 in stock
Refrigerate before use. For HPV and Cervical Dysplasia insert one suppository vaginally at bedtime twice per week. For best results use in conjunction with Green Tea Suppositories on alternate days twice per week.
This product may cause undergarment staining. Use of feminine pad is advised.
Refrigerate upon arrival. Keep refrigerated for duration of use. Store with box sitting upright with suppository tips facing down. It’s not uncommon for the suppositories to develop air bubbles during refrigeration, this does not affect the efficacy or use of the product.
Please ensure that this product is stored away from direct light and heat.
Store with a temperature range of 4°C (39°F) to 7°C (45°F). Avoid exposing to temperatures exceeding 30°C (86°F).
If irritation or discomfort occurs, discontinue use and see a doctor. For vaginal use only. Not for oral consumption. Keep out of the reach of children. Do not use if you are pregnant or nursing.
Curcumin Benefits
Curcumin, the major yellow pigment from the rhizomes of turmeric (Curcuma longa), has anticancer, anti-inflammatory, antioxidant, and antibacterial effects. In recent years, numerous in vitro and in vivo studies have found that curcumin can have significant efficacy in anti-cervical cancer treatment by promoting apoptosis (cell death), inhibiting tumor cell proliferation, metastasis and invasion, inhibiting HPV and inducing autophagy in tumor cells.(1,2) Infection with high-risk human papillomavirus can lead to the development of cervical carcinoma, predominately through the action of viral oncoproteins E6 and E7. Curcumin has been shown to selectively inhibit expression of E6 and E7 oncogenes as early as 6 hours post-treatment, while restoring the tumor suppression proteins p53, p21, p27, pRB, and PTPN13.(3,4,5,6,7) The up-regulation of these tumor suppression proteins inhibits HPV-induced dysplasia and cancer formation. Topical, or intravaginal curcumin, has also been shown to increase the clearance of HPV in a randomized, double-blind placebo-controlled study.(8)
(1) Basic research on curcumin in cervical cancer: Progress and perspectives. Biomed Pharmacother. 2023 Jun: 162:114590. doi: 10:1016/j.biopha.2023.114590. Epub 2023 Mar 23. Zhang X, et al
(2) Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells. Front Oncol. 2018 Oct 2:8:399. doi: 10.3389/fonc.2018.00399. eCollection 2018. Khan AQ, et al
(3) Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7. Mol Carcinog. 2011 Jan;50(1):47-57. doi: 10.11002/mc.20695. Maher DM, et al
(4) Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol Carcinog. 2006 May;45(5):320-32. doi: 10.1002/mc.20170. Divya CS, Pillai MR
(5) Elucidating Molecular Interactions of Natural Inhibitors with HPV-16 E6 Oncoprotein through Docking Analysis. Genomics Inform. 2014 Jun;12(2):64-70. doi: 10.5808/GI.2014.12.2.64. Epub 2014 Jun 30. Kumar S, et al
(6) A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells. Gynecol Oncol. 2013 Apr;129(1):145-53. doi: 10.1016/j.ygyno.2012.12.005. Epub 2012 Dec 9. Debata PR, et al
(7) Curcumin suppressed the proliferation and apoptosis of HPV-positive cervical cancer cells by directly targeting the E6 protein. Phytother Res. 2023 May 8. doi:10.1002/ptr.7868. Online ahead of print. Zhao X, et al
(8) Clearance of cervical human papillomavirus infection by topical application of curcumin and curcumin containing polyherbal cream: a phase II randomized controlled study. Asian Pac J Cancer Prev. 2013;14(10):5753-9. doi: 10.7314/apjcp.2013.14.10.5753. Basu P, et al