Green Tea Suppositories
$89.00
Green Tea vaginal suppositories for cervico-vaginal HPV infection.
24 Ovules • 3 Month Supply
92 in stock
Refrigerate before use. For HPV and Cervical Dysplasia insert one suppository vaginally at bedtime twice per week. For best results use in conjunction with Curcumin Suppositories on alternate days twice per week.
This product may cause undergarment staining. Use of feminine pad is advised.
Refrigerate upon arrival. Keep refrigerated for duration of use. Store with box sitting upright with suppository tips facing down. It’s not uncommon for the suppositories to develop air bubbles during refrigeration, this does not affect the efficacy or use of the product.
Please ensure that this product is stored away from direct light and heat.
Store with a temperature range of 4°C (39°F) to 7°C (45°F). Avoid exposing to temperatures exceeding 30°C (86°F).
If irritation or discomfort occurs, discontinue use and see a doctor. For vaginal use only. Not for oral consumption. Keep out of the reach of children. Do not use if you are pregnant or nursing.
Green Tea & Berberine Benefits
Epigallocatechin-3-gallate (ECGC), the primary bioactive polyphenol in green tea (Camellia sinensis), has been shown to inhibit the growth of HPV-transformed epithelial cells.(1) ECGC treatment is associated with degradation of the E6 and E7 oncoproteins and an upregulation of the tumor suppression genes p53 and pRb, therby inhibiting dysplasia and carcinogenisis.(1,2,3,4,5,6) Green tea is known to possess antiproliferative properties, inhibiting cervical cancer cell growth through induction of apoptosis (cell death) and cell cycle arrest as well as via the regulation of gene expression.(7,8)
Mahonia aquifolium, containing the alkaloid berberine, is known for its broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity.(9) Berberine has been shown to increase the activity of the p53 tumor suppression gene as well as help degrade the E6 and E7 oncoproteins which are an integral component of HPV carcinogenesis.(10,11,12) Berberine targets various steps in the viral life cycle, reducing virus replication and targets specific interactions between the virus and its host, thus leading to viral clearance.(9)
(1) The Major Constituent of Green Tea, Epigallocatechin-3-Gallate (EGCG), Inhibits the Growth of HPV18-Infected Keratinocytes by Stimulating Proteasomal Turnover of the E6 and E7 Oncoproteins. Pathogens. 2021 Apr 11;10(4):459. doi: 10.3390/pathogens10040459. Jason K W Yap, et al
(2) Green Tea Polyphenols Cause Apoptosis and Autophagy in HPV-16 Subgene-Immortalized Human Cervical Epithelial Cells via the Activation of the Nrf2 Pathway. Nutr Cancer. 2022;74(10):3769-3778. doi: 10.1080/01635581.2022.2093922. Epub 2022 Jun 30. Yi Tang, et al
(3) Preventing Persistence of HPV Infection with Natural Molecules. Pathogens. 2023 Mar 6;12(3):416. doi: 10.3390/pathogens12030416. Antonio Simone Lagana, et al
(4) Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression. Oncotarget.2017 Mar 29;8(37):60904-60916. doi: 10.18632/oncotarget.16648. eCollection 2017 Set 22. Mukherjee S, et al
(5) Elucidating Molecular Interactions of Natural Inhibitors with HPV-16 E6 Oncoprotein through Docking Analysis. Genomics Inform. 2014 Jun;12(2):64-70. doi: 10.5808/GI.2014.12.2.64. Epub 2014 Jun 30. Kumar S, et al
(6) TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma. Oncotarget. 2016 Jul 16;8(36):60025-60035. doi: 10.18632/oncotarget.10620.10620. eCollection 2017 Sep 1. Piao L, et al
(7) A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression. DNA Cell Biol. 2003 Mar;22(3):217-24. doi: 10.1089/104454903321655846. Woong Shick Ahn, et al
(8) Regulation of cell growth through cell cycle arrest and apoptosis in HPV 16 positive human cervical cancer cells by tea polyphenols. Invest New Drugs. 2010 Jun;28(3):216-24. doi: 10.1007/s10637-009-9240-x. Epub 2009 Mar 7. Madhulika Singh, et al
(9) Antiviral activity of berberine. Arch Virol. 2020 Sep;165(9):1935-1945. doi: 10.1007/s00705-020-04706-3. Epub 2020 Jun 28. Alicja Warowicka, et al
(10) Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium. Front Pharmacol. 2021 Oct 28:12:757414. doi: 10.3389/fphar.2021.757414. eCollection 2021. Tejveer Singh, et al
(11) Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6-E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: a mechanistic study including molecular docking. Eur J Pharmacol. 2014 Dec 5:744:132-46. doi: 10:1016/j.ejphar.2014.09.048. Epub 2014 Oct 18. Saha SK, Khuda-Bukhsh AR
(12) Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol Cancer. 2011 Apr 15:10:39. doi: 10.1186/1476-4598-10-39. Sutapa Mahata, et al